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Worsening macrocytic anemia : B 12 deficiency may also cause a macrocytic (megaloblastic) anemia BUT, in the presence of folate supplementation, this anemia may be masked so that B 12 deficiency may present with exclusively neurologic features

Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven

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Anecdotal reports of users running 6+ months show continued effectiveness without significant issues